This is pretty much an emotion versus reason argument. We COULD go to single pilot setup right now. It would increase the risk of each flight from "one in a kajillion" to "one in a bazzillion" chance of dying in a plane crash. The whole "unmanned airliner" concept could be technically sound in a few short years, moving us from "one in a bazzillion" to "one in a billion" chance of dying. Many of the other "innovations" that this guy suggests could be implemented right now as well (standing room areas, no sky-waitresses, etc) if the regulations allowed that.
The problem is that people aren't comfortable with that yet. They may never be. It just "feels wrong". Many believe (rightly or wrongly from a statistical standpoint) that having an actual human being who is trained and experienced in handling an airplane up front at the controls is worth the extra cost.
As soon (if ever) they allow a carrier to try some of these cost savings schemes, somebody is going to do it. It'll be interesting to see how they do. Not so much from the technical side. I'm sure it'll work 99.999% of the time, and I'm equally sure that 0.001% of the time some computer/kid with a PS3 controller is going to screw up and drive the plane into a mountain or run it out of gas. I'm more interested in how many travellers are willing to bet their life on those odds for a $50 ticket from LA to New York.
As a halfway solution, here's what I'd like to try if I ever get to run my own airline (and change a crap-ton of FARs):
Greyhound Air. Our slogan is "We'll get you there cheap, but it's going to suck."
I'd have internet-only sales of tickets (eliminating the checkin folks) and a "carry whatever you want" luggage system (eliminating the baggage handlers). Guns are fine, but no explosives allowed on the plane. The planes would be set up like a subway car. Bench seats along the sides and standing room in the middle. Perhaps some kind of security guard with a pistol and a nightstick could ride back there with the unwashed masses to break up fights and keep some sense of order.
Up front you'd have some kid fresh out of flight school with a couple of hundred hours ME time making about $20K/year. His sole job is to be a backup for the autopilot/UAV system that drives the plane. He would be sealed in the cockpit before the unwashed masses get there with absolutely no way of opening the hatch to the passenger compartment, or vice versa.
The only real expenses I'd have would be gas, maintenance, and the deathstar computer system that would sell the tickets, schedule the runs, and fly the planes. I wouldn't skimp on those ends.
My guess is that I'd make a ton of money until some calamity happens in the back (robbery/rape/murder) or if the plane crashes and they can pin it on my "pilot" system. Then the lawyers get involved. That's when most good ideas come crashing to a halt anyway.