Holy crap that seems like a LOT! No matter which way you cut it, that is a lot, right? (Right?)
(Somebody mentioned the DH Comet disasters of the 1950s earlier. Apples vs oranges comparison, but both of those happened at about 1,000 cycles.)
Jeem: I can't tell if you're making fun of me - but it really doesn't matter, it still seems like a lot to me. My point, if I have one, is that another pax a/c that stayed in service an incredibly long time was the DC-3. But it wasn't pressurized. No other high-usage, pressurized jet a/c is still around like the 737. Early DC-9s are long gone, and all but the -80s are also pretty much retired. I don't think the "metal balloon" analogy is a bad one, and there might just be some number certain of pressurization cycles an airframe can withstand before the damn rivets just start popping.