Over the years, whether through chamber rides or ROBD, I've got a pretty good handle on how my own hypoxic symptoms present. During my current tour, we've had three hypoxia events - all of which were events where only one crewmember has symptoms. I was an asymptomatic crewmember in one of those events. Though ROBD can not simulate the entire range of high altitude or histotoxic effects, the familiarity with one's own symptoms and physiological reactions - particularly when operating in the simulator - is far superior to the old quadrennial chamber ride requirement.