My best commuter hotel story doesn't involve a LaQuinta or a Denny's, although it was a Quality right across the street from a Denny's.
Really nice family business, like you can tell they're pitching in with who mans the front desk during the night, very accommodating to flight crew, super quick reservation over the phone if you've stayed there before, same with check in, good shuttle service...
Some knucklehead in the room across from mine must have started a fire in their room. I'm not really sure how, I mean any of the different rooms I ever stayed in I never noticed a single thing suspicious about wiring or the electrical appliances. The building was aging but at the same time they were investing in it and maintaining it, i.e. partial roof replacement going on one month, that kind of thing.
Anyway, as I was finishing my shower I thought I heard a ruckus. A few minutes later it got a lot louder followed by the sound of the fire alarm. Hmmm, don't want to be late. I was just about ready anyway, most of my stuff was already packed, and us pilots always seem to have a personal routine pretty much down to the minute- or better. Opened the door and stepped out into the hallway just like I always do, except this time there was moderately-thick smoke from about waist-height and up. The fire doors halfway down the hallway were now closed (and I may be dumb but I'm not dumb enough to use the elevator). So I marched down to the stairwell, carried my bags down a couple of flights, clipped them back together, and nonchalantly dropped off my room keycard at the front desk on my way out.
I also made sure my tie was straight before I left the room, same as always.
But again, not a LaQuinta (or BW, or...).