Well, it happened with the Wild Weasel mission, so don't count it out. There's not an ex-F-4G guy living who thinks the "automated" single-seat F-16 Weasel can do the mission as well as jets that have been in the boneyard for the last 12 years....
And the Weasel mission is half (at most) of the Prowler mission. No chance the radar, comms jamming, hard-kill mission can be done to the same level of capability with a single seat.
Heck, as an F-15E guy how possible is your full mission as a single seat? Sure you can do some just fine but when the workload and mission ramps up two heads can do a lot more. We aren't always going to be dealing with the threat environment we have now and we're buying jets for the next 20 years. We better get it right.
EW is not the glory job of the Air Wing. It's not a job that you can point to a video and say "hey look at the mess I made of the target" or that CENTCOM is going to talk about in his daily briefing to CNN. It's ethereal. You go out, work hard and do the best SEAD job you can and hope and pray that all your strikers get in an out unscathed and everyone's there for a slider back home. When they do, sit back and eat your slider with satisfaction, when someone doesn't, you pick it apart and see if there's anything you could have done or did that caused it and go out next cycle and press hard again. The feedback is usually that everyone's there, not video evidence. As EW and NW start to merge in SEAD this will become an even more elusive task.
If you can't live with that you should consider another platform.