While things have stabilized a bit lately I've known several Guard folks who've ended up on the short end of the stick when their units switched aircraft, sometimes to unmanned, or simply went away in a few cases. Start out flying F-16's, switch to C-21's then end up flying MQ-9's. You can switch units/states but you would be competing against others in the same boat for a diminishing number of spots, not a great scenario if you are too junior or too senior for what the remaining units are looking for.
Life is risk. Act accordingly. You'd still be accruing fixed wing time at a regional if you were hired on already, and orders are a way to pay the bills on ramen FO money at a regional.